VALUE OF ELEVATED SERUM MIRNA-143 LEVELS IN SEPSIS

HONG LI SHEN

Abstract


Target: To assess serum miniaturized scale RNA-143 (miR-143) levels in patients with sepsis or noninfectious systemic fiery reaction disorder (SIRS), and explore its conceivable symptomatic or prognostic worth.

Strategies: Serum was gotten from patients with sepsis or SIRS and sound control subjects. Relative miR-143 expression was resolved utilizing quantitative continuous polymerase chain response. The symptomatic and prognostic estimation of serum miR-143 was assessed.

Comes about: Serum miR-143 levels were essentially higher in patients with sepsis (n¼103) than patients with SIRS (n¼95) and sound controls (n¼40). There were noteworthy positive relationships between's serum miR-143 level and SOFA and APACHE II scores in patients with sepsis (r¼0.794 and r¼0.825, separately). Serum miR-143 had an affectability of 78.6% and specificity of 91.6% for recognizing sepsis and SIRS. There was no relationship between serum miR-143 and 28-day survival in patients with sepsis.

Conclusion: Serum miR-143 is lifted in patients with sepsis, and might be a helpful biomarker for recognizing sepsis and SIRS.


Full Text:

Untitled

References


Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ disappointment and rules for the utilization of inventive treatments in sepsis. The ACCP/SCCM accord gathering advisory group. American school of mid-section doctors/society of basic consideration drug. 1992. Mid-section 2009; 136(5 Suppl): e28.

Padkin A, Goldfrad C, Brady AR, et al. The study of disease transmission of serious sepsis happening in the initial 24 hrs in escalated care units in England, Wales, and Northern Ireland. Crit Care Med 2003; 31: 2332–2338.

Otto GP, Sossdorf M, Claus RA, et al. The late period of sepsis is portrayed by an expanded microbiological weight and passing rate. Crit Care 2011; 15: R183.

Osman A. MicroRNAs in wellbeing and disease– essential science and clinical applications. Clin Lab 2012; 58: 393–402.

Mendell JT and Olson EN. MicroRNAs in anxiety flagging and human sickness. Cell 2012; 148: 1172–1187.

Wang X, Gu H, Qin D, et al. Exosomal miR-223 adds to mesenchymal stem cellelicited cardioprotection in polymicrobial sepsis. Sci Rep 2015; 5: 13721.

Wang X, Wang X, Liu X, et al. miR-15a/16 are upreuglated in the serum of neonatal sepsis patients and repress the LPS-incited incendiary pathway. Int J Clin Exp Med 2015; 8: 5683–5690.

Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008; 18: 997–1006.

Chiam K, Wang T, Watson DI, et al. Circulating serum exosomal miRNAs as potential biomarkers for esophageal adenocarcinoma. J Gastrointest Surg 2015; 19:1208–1215.

Ludwig N, Nourkami-Tutdibi N, Backes C, et al. Circulating serum miRNAs as potential biomarkers for nephroblastoma. Pediatr Blood Cancer 2015; 62: 1360–1367.

Vasilescu C, Rossi S, Shimizu M, et al. MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One 2009; 4: e7405.

Wang L, Wang HC, Chen C, et al. Differential expression of plasma miR-146a in sepsis patients compared with non-sepsis- SIRS patients. Exp Ther Med 2013; 5: 1101–1104.

Wang H, Meng K, Chen WJ, et al. Serum miR-574-5p: a prognostic predictor of sepsis patients. Shock 2012; 37: 263–267.

Wang H, Zhang P, Chen W, et al. Evidence for serum miR-15a and miR-16 levels as biomarkers that distinguish sepsis from systemic inflammatory response syndrome in human subjects. Clin Chem Lab Med 2012;50: 1423–1428.

Wang Z, Ruan Z, Mao Y, et al. miR-27a is up regulated and promotes inflammatory response in sepsis. Cell Immunol 2014; 290: 190–195.

Schmidt WM, Spiel AO, Jilma B, et al. In vivo profile of the human leukocyte microRNA response to endotoxemia. Biochem Biophys Res Commun 2009; 380:437–441.

Ceppi M, Pereira PM, Dunand-Sauthier I, et al. MicroRNA-155 modulates the interleukin- 1 signaling pathway in activated human monocyte-derived dendritic cells.Proc Natl Acad Sci U S A 2009; 106: 2735–2740.

Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006; 103: 12481–12486.


Refbacks

  • There are currently no refbacks.